On March 18,2008 Dr. Heidi Russell spent a little over an hour speaking with families about neuroblastoma bone and bone marrow metastases.  Dr. Russell is a leader among the neuroblastoma research community.  One of her interests is in understanding how and why neuroblastoma commonly metastasizes to the bone.  Over the last several years, our understanding of the mechanism of bone metastasis in neuroblastoma has significantly improved.  Like *** cancer and myeloma, neuroblastoma cells activate osteoclasts to form osteolytic lesions.  Several targets for therapeutic intervention can now be identified.  Inhibition of osteoclast activation by bisphosphonates has already shown to be effective in preclinical models of neuroblastoma bone metastasis and is now be tested in phase I clinical studies.  Dr. Heidi Russell has been a pioneer in this area of research in neuroblastoma.  During this presentation she provides a review of our current understanding of the mechanisms involved in bone metastasis in neuroblastoma and discusses how this knowledge is leading to the identification of new targets for treatment. This presentation is targeted towards parents of children with neuroblastoma and those with an interest in understanding how neuroblastoma metastasizes to bone.  The video and its slide deck can be found below.

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